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Piperidine → 3-(3,5-Dimethyl-1H-pyrrol-2-ylmethylene)-5-(2-oxo-oxazolidin-3-ylmethyl)-1,3-dihydro-indol-2-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Piperidine | HCID 8082 | — |
| 反応物 | 3,5-Dimethyl-1H-pyrrole-2-carbaldehyde | HCID 270465 | — |
| 反応物 | 5-(2-Oxo-oxazolidin-3-ylmethyl)-1,3-dihydro-indol-2-one | HCID 66636156 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 3-(3,5-Dimethyl-1H-pyrrol-2-ylmethylene)-5-(2-oxo-oxazolidin-3-ylmethyl)-1,3-dihydro-indol-2-one | HCID 66636332 | — |
反応手順
A solution of 5-(2-oxo-oxazolidin-3-ylmethyl)-1,3-dihydro-indol-2-one (4.3 mmoles), 3,5-dimethyl-1H-pyrrole-2-carbaldehyde (5.17 mmoles) and piperidine (3 mmoles) in ethanol (30 ml) is heated at reflux for 24 hours. The solid formed is filtered off, washed with ethanol, with water and then with ethanol and dried in vacuo to yield the title product.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08133889B2 |
| 出典データセット | uspto-grants-2012_03 |
| ORD ID | ord-5a92623e9ef94385a2eb7c75576c415f |
| 出典メモ | uspto-grants-2012_03 |