6-Amino-1,3-dimethyluracil → HCID 59353132, compound

HRID 1094054Notes

Reaction equation

HRID 1094054 reaction equation
[F:1][C:2]1[CH:3]=[CH:4][C:5]([O:10][CH3:11])=[C:6]([CH:9]=1)[CH:7]=O.[NH2:12][C:13]1[N:18]([CH3:19])[C:17](=[O:20])[N:16]([CH3:21])[C:15](=[O:22])[CH:14]=1>>[NH2:16][C:15]1[C:14]([C:13]#[N:12])=[C:7]([C:6]2[CH:9]=[C:2]([F:1])[CH:3]=[CH:4][C:5]=2[O:10][CH3:11])[C:14]2[C:15](=[O:22])[N:16]([CH3:21])[C:17](=[O:20])[N:18]([CH3:19])[C:13]=2[N:12]=1

Participants

3

Reactant 2

HCID 811526-Amino-1,3-dimethyluracilHCID 27349435-Fluoro-2-methoxybenzaldehyde

Product 1

HCID 59353132HCID 59353132, compound

Procedure

7-amino-5-(5-fluoro-2-methoxyphenyl)-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrido[2,3-d]pyrimidine-6-carbonitrile (70a) was prepared by the reaction of 5-fluoro-2-methoxybenzaldehyde and 6-amino-1,3-dimethylpyrimidine-2,4(1H,3H)-dione, according to procedures described in the synthesis of Compound 56. MS [m+H] calc'd C17H15FN5O3 356; found 356.

Sources & evidence

ORD record
ord-ea0360106bc7463ca0d4faf36f3a7c18
Source dataset
uspto-grants-2012_03
Patent number
US08133898B2

Reaction notes

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