(3-Bromopropyl)benzene → HCID 25115525, compound

HRID 1094060Notes

Reaction equation

HRID 1094060 reaction equation
NC1C(C#N)=C(C2C=C(F)C=CC=2OC)C2C(=O)N(C)C(=O)N(C)C=2N=1.BrCCCC1C=CC=CC=1.[NH2:37][CH2:38][C:39]1[C:52]([NH:53][CH2:54][C:55]2C=C[C:62]3[C:57](=[CH:58][CH:59]=[CH:60][CH:61]=3)[CH:56]=2)=[N:51][C:42]2[N:43]([CH3:50])[C:44](=[O:49])[N:45]([CH3:48])[C:46](=[O:47])[C:41]=2[C:40]=1[C:65]1[CH:70]=[C:69]([F:71])[CH:68]=[CH:67][C:66]=1[O:72][CH3:73]>>[NH2:37][CH2:38][C:39]1[C:52]([NH:53][CH2:54][CH2:55][CH2:56][C:57]2[CH:62]=[CH:61][CH:60]=[CH:59][CH:58]=2)=[N:51][C:42]2[N:43]([CH3:50])[C:44](=[O:49])[N:45]([CH3:48])[C:46](=[O:47])[C:41]=2[C:40]=1[C:65]1[CH:70]=[C:69]([F:71])[CH:68]=[CH:67][C:66]=1[O:72][CH3:73]

Participants

4

Reactant 3

HCID 12503(3-Bromopropyl)benzeneHCID 24970297HCID 24970297, compoundHCID 59353132HCID 59353132, compound

Product 1

HCID 25115525HCID 25115525, compound

Procedure

The synthesis of title compounds started from Compound 70a and (3-bromopropyl)benzene, according to procedures described in the synthesis of Compound 70. 1H NMR (400 MHz, CHLOROFORM-d) δ ppm 2.41-2.53 (m, 2H) 3.16 (m, 2H) 3.68 (s, 3H) 3.77-3.83 (m, 2H) 3.96 (s, 3H) 4.16 (s, 3H) 4.20 (d, J=14.4 Hz, 1H) 7.71 (d, J=5.6 Hz, 1H) 7.14-7.21 (m, 1H) 7.42-7.48 (dd J=8.8, 4.3 Hz 1H) 7.61-7.65 (m, 3H) 7.69-7.74 (m, 2H). MS [m+H] calc'd C26H29FN5O3 478; found 478.

Workup

  1. customThe synthesis of title compounds

Sources & evidence

ORD record
ord-7c70f6bc613e44de8220c1a74d003219
Source dataset
uspto-grants-2012_03
Patent number
US08133898B2

Reaction notes

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