Hydrochloric Acid → HCID 66636915, compound

HRID 1094165Notes

Reaction equation

HRID 1094165 reaction equation
[CH:1]1([N:6]2[C:15]3[C:10](=[CH:11][CH:12]=[C:13]([F:16])[CH:14]=3)[C:9](=[O:17])[C:8]([C:18]([O:20]CC)=[O:19])=[CH:7]2)[CH2:5][CH2:4][CH2:3][CH2:2]1.Cl>C(O)(=O)C>[CH:1]1([N:6]2[C:15]3[C:10](=[CH:11][CH:12]=[C:13]([F:16])[CH:14]=3)[C:9](=[O:17])[C:8]([C:18]([OH:20])=[O:19])=[CH:7]2)[CH2:2][CH2:3][CH2:4][CH2:5]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 66637073HCID 66637073, compound

Product 1

HCID 66636915HCID 66636915, compoundYield 86.9%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Conditions

Temperature
120 °C

Procedure

900 mg of ethyl 1-cyclopentyl-7-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylate was dissolved in 6.4 ml of acetic acid, and 0.8 ml of 6 M hydrochloric acid was added, followed by overnight stirring at 120° C. The resulting reaction mixture was cooled to room temperature, and the insoluble materials were collected by filtration and washed with water to obtain 710 mg of 1-cyclopentyl-7-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid.

Workup

  1. customThe resulting reaction mixture
  2. temperaturewas cooled to room temperature
  3. filtrationthe insoluble materials were collected by filtration
  4. washwashed with water

Sources & evidence

ORD record
ord-f3792f73e57342fd90d10327bdf13178
Source dataset
uspto-grants-2012_03
Patent number
US08133882B2

Reaction notes

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