Hydrogen chloride-ethyl acetate → HCID 131729493, compound

HRID 1094202Notes

Reaction equation

HRID 1094202 reaction equation
C(OC(=O)C)C.[ClH:7].[CH2:8]([O:10][C:11](=[O:36])[CH2:12][NH:13][CH2:14][C:15]1[C:24](=[O:25])[C:23]2[C:18](=[CH:19][C:20]([NH:27][CH:28]3[CH2:33][CH2:32][CH2:31][CH2:30][CH2:29]3)=[C:21]([F:26])[CH:22]=2)[N:17]([CH2:34][CH3:35])[CH:16]=1)[CH3:9]>C(OCC)(=O)C>[ClH:7].[CH2:8]([O:10][C:11](=[O:36])[CH2:12][NH:13][CH2:14][C:15]1[C:24](=[O:25])[C:23]2[C:18](=[CH:19][C:20]([NH:27][CH:28]3[CH2:33][CH2:32][CH2:31][CH2:30][CH2:29]3)=[C:21]([F:26])[CH:22]=2)[N:17]([CH2:34][CH3:35])[CH:16]=1)[CH3:9]

Participants

4

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 90927244HCID 90927244, compound

Product 1

HCID 131729493HCID 131729493, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

3 ml of ethyl acetate and 0.35 ml of a 1 M hydrogen chloride ethyl acetate solution were added to 0.13 g of ethyl({[7-(cyclohexylamino)-1-ethyl-6-fluoro-4-oxo-1,4-dihydroquinolin-3-yl]methyl}amino)acetate obtained by the same method of Example 9. After evaporation of the solvent under a reduced pressure and subsequent addition of ether, the insoluble materials were collected by filtration to obtain 97 mg of ethyl({[7-(cyclohexylamino)-1-ethyl-6-fluoro-4-oxo-1,4-dihydroquinolin-3-yl]methyl}amino)acetate hydrochloride.

Workup

  1. customobtained by the same method of Example 9
  2. customAfter evaporation of the solvent
  3. additionunder a reduced pressure and subsequent addition of ether
  4. filtrationthe insoluble materials were collected by filtration

Sources & evidence

ORD record
ord-2d03e80aa99d4a6098a966e272c34aae
Source dataset
uspto-grants-2012_03
Patent number
US08133882B2

Reaction notes

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