反应详情

温度

70 °C

To 500 mg of 7-(cyclohexylamino)-1-cyclopentyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carbaldehyde were added 5 ml of ethanol, 460 mg of sodium acetate and 290 mg of hydroxylamine hydrochloride, followed by stirring at room temperature for 15 hours and at 70° C. for 12 hours. The solvent was evaporated under a reduced pressure, and water was added to the resulting residue, followed by extraction with chloroform and washing with aqueous saturated sodium chloride. After drying over anhydrous sodium sulfate, the solvent was evaporated under a reduced pressure to obtain 300 mg of 7-(cyclohexylamino)-1-cyclopentyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carbaldehyde oxime.

1. customThe solvent was evaporated under a reduced pressure, and water
2. additionwas added to the resulting residue
3. extractionfollowed by extraction with chloroform
4. washwashing with aqueous saturated sodium chloride
5. dry with materialAfter drying over anhydrous sodium sulfate
6. customthe solvent was evaporated under a reduced pressure