反应详情

To a cold (˜0° C.) solution of (R)-3-(5-bromo-pyrimidin-2-ylamino)-piperidine-1-carboxylic acid tert-butyl ester (775 mg) in dry DCM (10 mL) was added slowly TFA (0.831 mL). The reaction mixture was stirred at RT for 20 h, 5 eq more of TFA (0.831 mL) was added and the stirring was continued for 2 h. The reaction was concentrated in vacuo to yield the title compound as a bis-trifluoroacetate salt which was used for the next step without further purification.

1. waitthe stirring was continued for 2 h
2. concentrationThe reaction was concentrated in vacuo