2-(3,4-dimethylphenyl)benzoic Acid → (R)-[3-(5-Bromo-pyrimidin-2-ylamino)-piperidin-1-yl]-(3',4'-dimethyl-biphenyl-2-yl)-methanone

HRID 1094265Notes

Reaction equation

HRID 1094265 reaction equation
[CH3:1][C:2]1[CH:3]=[C:4]([C:9]2[C:10]([C:15]([OH:17])=O)=[CH:11][CH:12]=[CH:13][CH:14]=2)[CH:5]=[CH:6][C:7]=1[CH3:8].[Br:18][C:19]1[CH:20]=[N:21][C:22]([NH:25][C@@H:26]2[CH2:31][CH2:30][CH2:29][NH:28][CH2:27]2)=[N:23][CH:24]=1>>[Br:18][C:19]1[CH:20]=[N:21][C:22]([NH:25][C@@H:26]2[CH2:31][CH2:30][CH2:29][N:28]([C:15]([C:10]3[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=3[C:4]3[CH:5]=[CH:6][C:7]([CH3:8])=[C:2]([CH3:1])[CH:3]=3)=[O:17])[CH2:27]2)=[N:23][CH:24]=1

Participants

3

Reactant 2

HCID 27585452-(3,4-dimethylphenyl)benzoic AcidHCID 66639492HCID 66639492, compound

Product 1

HCID 24963402(R)-[3-(5-Bromo-pyrimidin-2-ylamino)-piperidin-1-yl]-(3',4'-dimethyl-biphenyl-2-yl)-methanone

Procedure

prepared by reaction of 3′,4′-dimethyl-biphenyl-2-carboxylic acid with (R)-(5-bromo-pyrimidin-2-yl)-piperidine-3-yl-amine.

Sources & evidence

ORD record
ord-e01481076d0446ce87bb4e970cd94f71
Source dataset
uspto-grants-2012_03
Patent number
US08133901B2

Reaction notes

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