5-Propylthiophene-2-carboxylic acid → 2-Ethyl-6-methyl-4-[5-(5-propyl-thiophen-2-yl)-[1,2,4]oxadiazol-3-yl]-phenol

HRID 1094309Notes

Reaction equation

HRID 1094309 reaction equation
[CH2:1]([C:4]1[S:8][C:7]([C:9]([OH:11])=O)=[CH:6][CH:5]=1)[CH2:2][CH3:3].[CH2:12]([C:14]1[CH:15]=[C:16]([CH:21]=[C:22]([CH3:25])[C:23]=1[OH:24])[C:17]([NH:19]O)=[NH:18])[CH3:13]>>[CH2:12]([C:14]1[CH:15]=[C:16]([C:17]2[N:19]=[C:9]([C:7]3[S:8][C:4]([CH2:1][CH2:2][CH3:3])=[CH:5][CH:6]=3)[O:11][N:18]=2)[CH:21]=[C:22]([CH3:25])[C:23]=1[OH:24])[CH3:13]

Participants

3

Reactant 2

HCID 31643145-Propylthiophene-2-carboxylic acidHCID 178436626HCID 178436626, compound

Product 1

HCID 1360299422-Ethyl-6-methyl-4-[5-(5-propyl-thiophen-2-yl)-[1,2,4]oxadiazol-3-yl]-phenol

Procedure

2-Ethyl-6-methyl-4-[5-(5-propyl-thiophen-2-yl)-[1,2,4]oxadiazol-3-yl]-phenol is prepared in analogy to Example 1 starting from 5-propyl-thiophene-2-carboxylic acid and 3-ethyl-4,N-dihydroxy-5-methyl-benzamidine; LC-MS: tR=1.12 min, [M+1]+=329.14.

Sources & evidence

ORD record
ord-46f4b53e6ca14fd8bf9d8a2f832a4963
Source dataset
uspto-grants-2012_03
Patent number
US08133910B2

Reaction notes

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