反应详情

温度

80 °C

A solution of 5,6,7,8-tetrahydro-naphthalen-2-ylamine (1.132 g, 6.08 mmol, commercially available) and (6-trifluoromethyl-pyridin-3-yl)-acetonitrile (distilled 166-175° C./2 mb, 0.985 g, 6.69 mmol, prepared as per example 1, step 1) in MeOH (10 mL) was treated with HCO2NH4 (2.301 g, 36.5 mmol) and 10% Pd/C (250 mg) and stirred at 80° C. for 1.5 h. Filtration, concentration and purification by chromatography (SiO2, heptane:ethyl acetate=95:5 to 60:40) afforded the title compound (1.333 g, 68%) as an off-white solid. MS m/e: 321.1 [M+H]+.

1. filtrationFiltration, concentration and purification by chromatography (SiO2, heptane:ethyl acetate=95:5 to 60:40)