Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 1094343생성일: 2026년 10월 25일
5,6,7,8-Tetrahydro-2-naphthylamine → (5,6,7,8-Tetrahydro-naphthalen-2-yl)-[2-(6-trifluoromethyl-pyridin-3-yl)-ethyl]-amine
https://huagongshe.com/reaction/1094343
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 5,6,7,8-Tetrahydro-2-naphthylamine | HCID 75193 | — |
| 반응물 | 3-Pyridineacetonitrile, 6-(trifluoromethyl)- | HCID 50851127 | — |
| 촉매 | Palladium | HCID 23938 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | (5,6,7,8-Tetrahydro-naphthalen-2-yl)-[2-(6-trifluoromethyl-pyridin-3-yl)-ethyl]-amine | HCID 58007563 | 68% |
반응 단계
A solution of 5,6,7,8-tetrahydro-naphthalen-2-ylamine (1.132 g, 6.08 mmol, commercially available) and (6-trifluoromethyl-pyridin-3-yl)-acetonitrile (distilled 166-175° C./2 mb, 0.985 g, 6.69 mmol, prepared as per example 1, step 1) in MeOH (10 mL) was treated with HCO2NH4 (2.301 g, 36.5 mmol) and 10% Pd/C (250 mg) and stirred at 80° C. for 1.5 h. Filtration, concentration and purification by chromatography (SiO2, heptane:ethyl acetate=95:5 to 60:40) afforded the title compound (1.333 g, 68%) as an off-white solid. MS m/e: 321.1 [M+H]+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US08133909B2 |
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| 출처 데이터셋 | uspto-grants-2012_03 |
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| ORD ID | ord-26c516f9aee442f89d739312d88b16e4 |
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| 출처 메모 | uspto-grants-2012_03 |
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