Oxo(pyridin-3-yl)acetic acid → HCID 58007490, compound

HRID 1094346Notes

Reaction equation

HRID 1094346 reaction equation
[CH3:1][C:2]1[CH:3]=[C:4]([NH:9][CH2:10][CH2:11][C:12]2[CH:13]=[N:14][C:15]([C:18]([F:21])([F:20])[F:19])=[CH:16][CH:17]=2)[CH:5]=[CH:6][C:7]=1[CH3:8].[O:22]=[C:23]([C:27]1[CH:28]=[N:29][CH:30]=[CH:31][CH:32]=1)[C:24](O)=[O:25]>>[CH3:1][C:2]1[CH:3]=[C:4]([N:9]([CH2:10][CH2:11][C:12]2[CH:13]=[N:14][C:15]([C:18]([F:21])([F:20])[F:19])=[CH:16][CH:17]=2)[C:24](=[O:25])[C@@H:23]([OH:22])[C:27]2[CH:28]=[N:29][CH:30]=[CH:31][CH:32]=2)[CH:5]=[CH:6][C:7]=1[CH3:8]

Participants

3

Reactant 2

HCID 13548099Oxo(pyridin-3-yl)acetic acidHCID 58007591(3,4-Dimethyl-phenyl)-[2-(6-trifluoromethyl-pyridin-3-yl)-ethyl]-amine

Product 1

HCID 58007490HCID 58007490, compoundYield 27%

Procedure

In analogy to example 7, (3,4-dimethyl-phenyl)-[2-(6-trifluoromethyl-pyridin-3-yl)-ethyl]-amine (250 mg, 0.85 mmol) and oxo-pyridin-3-yl-acetic acid (343 mg, 1.27 mmol, CAS 39684-37-2) were coupled together to afford the title compound (48 mg, 27%) as a colourless solid. MS m/e: 430.2 [M+H]+.

Sources & evidence

ORD record
ord-f19bf898ec6c46939d271b566d25fb89
Source dataset
uspto-grants-2012_03
Patent number
US08133909B2

Reaction notes

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