Benzene, 2-methoxy-1-methyl-4-nitro- → HCID 58007507, compound

HRID 1094352Notes

Reaction equation

HRID 1094352 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[C:7]([N+:9]([O-])=O)[CH:6]=[CH:5][C:4]=1[CH3:12].[F:13][C:14]([F:25])([F:24])[C:15]1[N:20]=[CH:19][C:18]([CH2:21][C:22]#N)=[CH:17][CH:16]=1>>[CH3:1][O:2][C:3]1[CH:8]=[C:7]([NH:9][CH2:22][CH2:21][C:18]2[CH:19]=[N:20][C:15]([C:14]([F:25])([F:13])[F:24])=[CH:16][CH:17]=2)[CH:6]=[CH:5][C:4]=1[CH3:12]

Participants

3

Reactant 2

HCID 83159Benzene, 2-methoxy-1-methyl-4-nitro-HCID 508511273-Pyridineacetonitrile, 6-(trifluoromethyl)-

Product 1

HCID 58007507HCID 58007507, compoundYield 31.3%

Procedure

In analogy to example 6, step 1, 2-methoxy-1-methyl-4-nitro-benzene (988 mg, 5.91 mmol) was coupled to (6-trifluoromethyl-pyridin-3-yl)-acetonitrile (1.0 g, 5.37 mmol, prepared in example 1, step 1) to give the title compound (521 mg, 31%) as an orange oil MS m/e: 311.1 [M+H]+.

Sources & evidence

ORD record
ord-5bbc0af40c464663bb4942e754a22f99
Source dataset
uspto-grants-2012_03
Patent number
US08133909B2

Reaction notes

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