Trifluoroacetic acid → HCID 58007492, compound

HRID 1094374Notes

Reaction equation

HRID 1094374 reaction equation
C(O)(C(F)(F)F)=O.[CH3:8][O:9][C:10]1[N:15]=[CH:14][C:13]([NH:16][CH2:17][CH2:18][C:19]2[CH:24]=[CH:23][C:22]([C:25]([F:28])([F:27])[F:26])=[CH:21][CH:20]=2)=[CH:12][CH:11]=1.[CH3:29][O:30][C:31]1[CH:36]=[CH:35][CH:34]=[CH:33][C:32]=1[CH2:37][C:38](O)=[O:39]>>[CH3:29][O:30][C:31]1[CH:36]=[CH:35][CH:34]=[CH:33][C:32]=1[CH2:37][C:38]([N:16]([C:13]1[CH:14]=[N:15][C:10]([O:9][CH3:8])=[CH:11][CH:12]=1)[CH2:17][CH2:18][C:19]1[CH:24]=[CH:23][C:22]([C:25]([F:28])([F:27])[F:26])=[CH:21][CH:20]=1)=[O:39]

Participants

4

Reactant 3

HCID 6422Trifluoroacetic acidHCID 71342-Methoxyphenylacetic acidHCID 57591491HCID 57591491, compound

Product 1

HCID 58007492HCID 58007492, compound

Procedure

In analogy to example 33, step 2, without TFA addition, (6-methoxy-pyridin-3-yl)-[2-(4-trifluoromethyl-phenyl)-ethyl]-amine, prepared in example 33, step 1) was coupled to (2-methoxy-phenyl)-acetic acid (commercially available) to give the title compound. MS m/e: 445.3 [M+H]+.

Workup

  1. customprepared in example 33, step 1)

Sources & evidence

ORD record
ord-13baa20fe02c413980414392cd56694f
Source dataset
uspto-grants-2012_03
Patent number
US08133909B2

Reaction notes

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