6-Aminobenzothiazole → Benzothiazol-6-yl-[2-(4-trifluoromethyl-phenyl)-ethyl]-amine

HRID 1094375Notes

Reaction equation

HRID 1094375 reaction equation
[F:1][C:2]([F:14])([F:13])[C:3]1[CH:8]=[CH:7][C:6]([CH2:9][C:10](O)=O)=[CH:5][CH:4]=1.[S:15]1[C:19]2[CH:20]=[C:21]([NH2:24])[CH:22]=[CH:23][C:18]=2[N:17]=[CH:16]1>>[S:15]1[C:19]2[CH:20]=[C:21]([NH:24][CH2:10][CH2:9][C:6]3[CH:7]=[CH:8][C:3]([C:2]([F:14])([F:13])[F:1])=[CH:4][CH:5]=3)[CH:22]=[CH:23][C:18]=2[N:17]=[CH:16]1

Participants

3

Reactant 2

HCID 682886-AminobenzothiazoleHCID 118342(alpha,alpha,alpha-Trifluoro-4-tolyl)acetic acid

Product 1

HCID 57570295Benzothiazol-6-yl-[2-(4-trifluoromethyl-phenyl)-ethyl]-amine

Procedure

In analogy to example 33, step 1, (4-trifluoromethyl-phenyl)-acetic acid (commercially available) was coupled with benzothiazol-6-ylamine (commercially available) to give the title compound.

Sources & evidence

ORD record
ord-43a17e90f21243238873c886b0cd9da7
Source dataset
uspto-grants-2012_03
Patent number
US08133909B2

Reaction notes

Loading…