(alpha,alpha,alpha-Trifluoro-4-tolyl)acetic acid → HCID 58007607, compound

HRID 1094380Notes

Reaction equation

HRID 1094380 reaction equation
[F:1][C:2]([F:14])([F:13])[C:3]1[CH:8]=[CH:7][C:6]([CH2:9][C:10](O)=O)=[CH:5][CH:4]=1.[CH3:15][O:16][C:17]1[C:22]([NH2:23])=[CH:21][CH:20]=[CH:19][N:18]=1>>[CH3:15][O:16][C:17]1[C:22]([NH:23][CH2:10][CH2:9][C:6]2[CH:7]=[CH:8][C:3]([C:2]([F:14])([F:13])[F:1])=[CH:4][CH:5]=2)=[CH:21][CH:20]=[CH:19][N:18]=1

Participants

3

Reactant 2

HCID 118342(alpha,alpha,alpha-Trifluoro-4-tolyl)acetic acidHCID 27374883-Amino-2-methoxypyridine

Product 1

HCID 58007607HCID 58007607, compound

Procedure

In analogy to example 33, step 1, (4-trifluoromethyl-phenyl)-acetic acid (commercially available) was coupled with 2-methoxy-pyridin-3-ylamine (commercially available) to give the title compound.

Sources & evidence

ORD record
ord-7a2e1d6687b84e89bc7160cdeaa847eb
Source dataset
uspto-grants-2012_03
Patent number
US08133909B2

Reaction notes

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