HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Aminoquinoline → (S)-2-Hydroxy-2-phenyl-N-quinolin-3-yl-N-[2-(6-trifluoromethyl-pyridin-3-yl)-ethyl]-acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Aminoquinoline | HCID 11375 | — |
| Reactant | 3-Pyridineacetonitrile, 6-(trifluoromethyl)- | HCID 50851127 | — |
| Reactant | acetyl (2S)-2-hydroxy-2-phenylacetate | HCID 87431886 | — |
| Product | (S)-2-Hydroxy-2-phenyl-N-quinolin-3-yl-N-[2-(6-trifluoromethyl-pyridin-3-yl)-ethyl]-acetamide | HCID 44545787 | — |
Reaction Steps
In analogy to example 47 (step 2) and example 48 (steps 3 & 4), Quinolin-3-ylamine, (6-Trifluoromethyl-pyridin-3-yl)-acetonitrile & (S)-(+)-O-acetyl-L-mandelic acid were successively coupled and hydrolysed to give the target compound. MS(m/e): 452.1 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08133909B2 |
| Source dataset | uspto-grants-2012_03 |
| ORD ID | ord-8176aa8c47a64ad6bb90e8e0e73fe076 |
| Source note | uspto-grants-2012_03 |