HuagongsheHuagongshe Chemistry Print Report · For research reference only
5,6,7,8-Tetrahydro-2-naphthylamine → (S)-2-(4-Fluoro-phenyl)-2-hydroxy-N-(5,6,7,8-tetrahydro-naphthalen-2-yl)-N-[2-(6-trifluoromethyl-pyridin-3-yl)-ethyl]-acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5,6,7,8-Tetrahydro-2-naphthylamine | HCID 75193 | — |
| Reactant | 2-(4-Fluorophenyl)-2-oxoacetic Acid | HCID 579440 | — |
| Reactant | 3-Pyridineacetonitrile, 6-(trifluoromethyl)- | HCID 50851127 | — |
| Product | (S)-2-(4-Fluoro-phenyl)-2-hydroxy-N-(5,6,7,8-tetrahydro-naphthalen-2-yl)-N-[2-(6-trifluoromethyl-pyridin-3-yl)-ethyl]-acetamide | HCID 44546438 | — |
Reaction Steps
In analogy to example 47 (steps 3 & 4), 5,6,7,8-Tetrahydro-naphthalen-2-ylamine, (6-Trifluoromethyl-pyridin-3-yl)-acetonitrile & (4-Fluoro-phenyl)-oxo-acetic acid were successively coupled then reduced to give after chiral chromatography (+ve rotation) the target compound. MS(m/e): 473.1 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08133909B2 |
| Source dataset | uspto-grants-2012_03 |
| ORD ID | ord-e3eca01a8f8a4393a9294845399bf821 |
| Source note | uspto-grants-2012_03 |