HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Methoxy-4-methylaniline → (S)-2-(4-Fluoro-phenyl)-2-hydroxy-N-(3-methoxy-4-methyl-phenyl)-N-[2-(6-trifluoromethyl-pyridin-3-yl)-ethyl]-acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Methoxy-4-methylaniline | HCID 27882 | — |
| Reactant | 2-(4-Fluorophenyl)-2-oxoacetic Acid | HCID 579440 | — |
| Reactant | 3-Pyridineacetonitrile, 6-(trifluoromethyl)- | HCID 50851127 | — |
| Product | (S)-2-(4-Fluoro-phenyl)-2-hydroxy-N-(3-methoxy-4-methyl-phenyl)-N-[2-(6-trifluoromethyl-pyridin-3-yl)-ethyl]-acetamide | HCID 44546439 | — |
Reaction Steps
In analogy to example 47 (steps 3 & 4), 3-Methoxy-4-methyl-phenylamine, (6-Trifluoromethyl-pyridin-3-yl)-acetonitrile & (4-Fluoro-phenyl)-oxo-acetic acid were successively coupled then reduced to give after chiral chromatography (+ve rotation) the target compound. MS(m/e): 463.1 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08133909B2 |
| Source dataset | uspto-grants-2012_03 |
| ORD ID | ord-a9fee316c56f44909681482eb49d0295 |
| Source note | uspto-grants-2012_03 |