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HRID1094410

反应详情

EQUATION

反应方程式

HRID 1094410 的结构方程式

REACTANTS

反应物

3
结构：COc1cc(N)ccc1C
HCID27882

3-Methoxy-4-methylaniline

C8H11NO

结构：O=C(O)C(=O)c1ccc(F)cc1
HCID579440

未命名化合物

结构：N#CCc1ccc(C(F)(F)F)nc1
HCID50851127

未命名化合物

PRODUCTS

生成物

1
结构：COc1cc(N(CCc2ccc(C(F)(F)F)nc2)C(=O)[C@@H](O)c2ccc(F)cc2)ccc1C
HCID44546439

未命名化合物

PROCEDURE

实验过程

In analogy to example 47 (steps 3 & 4), 3-Methoxy-4-methyl-phenylamine, (6-Trifluoromethyl-pyridin-3-yl)-acetonitrile & (4-Fluoro-phenyl)-oxo-acetic acid were successively coupled then reduced to give after chiral chromatography (+ve rotation) the target compound. MS(m/e): 463.1 [M+H]+.

WORKUP

后处理

  1. customto give after chiral chromatography (+ve rotation) the target compound