Indan-5-amine → Indan-5-yl-[2-(5-trifluoromethyl-pyridin-2-yl)-ethyl]-amine

HRID 1094417Notes

Reaction equation

HRID 1094417 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[CH2:7][CH2:6][CH2:5]2.[F:11][C:12]([F:22])([F:21])[C:13]1[CH:14]=[CH:15][C:16]([CH:19]=[CH2:20])=[N:17][CH:18]=1>>[CH2:7]1[C:8]2[C:4](=[CH:3][C:2]([NH:1][CH2:20][CH2:19][C:16]3[CH:15]=[CH:14][C:13]([C:12]([F:22])([F:11])[F:21])=[CH:18][N:17]=3)=[CH:10][CH:9]=2)[CH2:5][CH2:6]1

Participants

3

Reactant 2

HCID 90496Indan-5-amineHCID 589339925-(Trifluoromethyl)-2-vinylpyridine

Product 1

HCID 66637455Indan-5-yl-[2-(5-trifluoromethyl-pyridin-2-yl)-ethyl]-amine

Procedure

In analogy to the procedure described for the synthesis example 25 (step 1), the title compound Indan-5-yl-[2-(5-trifluoromethyl-pyridin-2-yl)-ethyl]-amine (MS m/e: 307.2 [M+H]+) was prepared from 5-amino-indan instead of 3,4-dimethylaniline and 5-trifluoromethyl-2-vinyl-pyridine.

Workup

  1. customIn analogy to the procedure described for the synthesis example 25 (step 1)

Sources & evidence

ORD record
ord-5b9e3e3c5d974a0094c68b27e085f85f
Source dataset
uspto-grants-2012_03
Patent number
US08133909B2

Reaction notes

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