4-Isopropylaniline → (4-Isopropyl-phenyl)-[2-(5-trifluoromethyl-pyridin-2-yl)-ethyl]-amine

HRID 1094418Notes

Reaction equation

HRID 1094418 reaction equation
[CH:1]([C:4]1[CH:10]=[CH:9][C:7]([NH2:8])=[CH:6][CH:5]=1)([CH3:3])[CH3:2].[F:11][C:12]([F:22])([F:21])[C:13]1[CH:14]=[CH:15][C:16]([CH:19]=[CH2:20])=[N:17][CH:18]=1>>[CH:1]([C:4]1[CH:10]=[CH:9][C:7]([NH:8][CH2:20][CH2:19][C:16]2[CH:15]=[CH:14][C:13]([C:12]([F:22])([F:11])[F:21])=[CH:18][N:17]=2)=[CH:6][CH:5]=1)([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 74644-IsopropylanilineHCID 589339925-(Trifluoromethyl)-2-vinylpyridine

Product 1

HCID 66637128(4-Isopropyl-phenyl)-[2-(5-trifluoromethyl-pyridin-2-yl)-ethyl]-amine

Procedure

In analogy to the procedure described for the synthesis example 25 (step 1), the title compound (4-isopropyl-phenyl)-[2-(5-trifluoromethyl-pyridin-2-yl)-ethyl]-amine (MS m/e: 309.2 [M+H]+) was prepared from 4-isopropylaniline instead of 3,4-dimethylaniline and 5-trifluoromethyl-2-vinyl-pyridine.

Workup

  1. customIn analogy to the procedure described for the synthesis example 25 (step 1)

Sources & evidence

ORD record
ord-8e1263ead5e14534a93a00703b85016d
Source dataset
uspto-grants-2012_03
Patent number
US08133909B2

Reaction notes

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