5-Bromo-2,3-dihydro-1-benzofuran → HCID 58007496, compound

HRID 1094419Notes

Reaction equation

HRID 1094419 reaction equation
Br[C:2]1[CH:3]=[CH:4][C:5]2[O:9][CH2:8][CH2:7][C:6]=2[CH:10]=1.[F:11][C:12]([F:23])([F:22])[C:13]1[CH:14]=[CH:15][C:16]([CH2:19][CH2:20][NH2:21])=[N:17][CH:18]=1>>[O:9]1[C:5]2[CH:4]=[CH:3][C:2]([NH:21][CH2:20][CH2:19][C:16]3[CH:15]=[CH:14][C:13]([C:12]([F:23])([F:11])[F:22])=[CH:18][N:17]=3)=[CH:10][C:6]=2[CH2:7][CH2:8]1

Participants

3

Reactant 2

HCID 27761595-Bromo-2,3-dihydro-1-benzofuranHCID 180713442-(5-Trifluoromethyl-pyridin-2-YL)-ethylamine

Product 1

HCID 58007496HCID 58007496, compound

Procedure

In analogy to the procedure described for the synthesis example 71 (step 1), the title compound (2,3-dihydro-benzofuran-5-yl)-[2-(5-trifluoromethyl-pyridin-2-yl)-ethyl]-amine (MS m/e: 309.0 [M+H]+) was prepared from 5-bromo-2,3-dihydro-1-benzofuran instead of 6-bromo-2,3-dihydro-benzofuran and 2-(5-trifluoromethyl-pyridin-2-yl)-ethylamine instead of 2-(6-trifluoromethyl-pyridin-3-yl)-ethylamine.

Workup

  1. customIn analogy to the procedure described for the synthesis example 71 (step 1)

Sources & evidence

ORD record
ord-553f8e4769794c8ea21d9f73892b414c
Source dataset
uspto-grants-2012_03
Patent number
US08133909B2

Reaction notes

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