1-Bromo-4-ethylbenzene → (4-Ethyl-phenyl)-[2-(5-trifluoromethyl-pyridin-2-yl)-ethyl]-amine

HRID 1094424Notes

Reaction equation

HRID 1094424 reaction equation
Br[C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH3:9])=[CH:4][CH:3]=1.[F:10][C:11]([F:22])([F:21])[C:12]1[CH:13]=[CH:14][C:15]([CH2:18][CH2:19][NH2:20])=[N:16][CH:17]=1>>[CH2:8]([C:5]1[CH:6]=[CH:7][C:2]([NH:20][CH2:19][CH2:18][C:15]2[CH:14]=[CH:13][C:12]([C:11]([F:22])([F:10])[F:21])=[CH:17][N:16]=2)=[CH:3][CH:4]=1)[CH3:9]

Participants

3

Reactant 2

HCID 153131-Bromo-4-ethylbenzeneHCID 180713442-(5-Trifluoromethyl-pyridin-2-YL)-ethylamine

Product 1

HCID 58007546(4-Ethyl-phenyl)-[2-(5-trifluoromethyl-pyridin-2-yl)-ethyl]-amine

Procedure

In analogy to the procedure described for the synthesis example 71 (step 1), the title compound (4-ethyl-phenyl)-[2-(5-trifluoromethyl-pyridin-2-yl)-ethyl]-amine (MS m/e: 295.2 [M+H]+) was prepared from 1-bromo-4-ethyl-benzene instead of 6-bromo-2,3-dihydro-benzofuran and 2-(5-trifluoromethyl-pyridin-2-yl)-ethylamine instead of 2-(6-trifluoromethyl-pyridin-3-yl)-ethylamine.

Workup

  1. customIn analogy to the procedure described for the synthesis example 71 (step 1)

Sources & evidence

ORD record
ord-6cf4e78b43c74dfeb805e948adc3b76c
Source dataset
uspto-grants-2012_03
Patent number
US08133909B2

Reaction notes

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