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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1094424Generated: October 26, 2026

1-Bromo-4-ethylbenzene → (4-Ethyl-phenyl)-[2-(5-trifluoromethyl-pyridin-2-yl)-ethyl]-amine

https://huagongshe.com/reaction/1094424

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-Bromo-4-ethylbenzeneHCID 15313—
Reactant2-(5-Trifluoromethyl-pyridin-2-YL)-ethylamineHCID 18071344—
Product(4-Ethyl-phenyl)-[2-(5-trifluoromethyl-pyridin-2-yl)-ethyl]-amineHCID 58007546—

Reaction Steps

In analogy to the procedure described for the synthesis example 71 (step 1), the title compound (4-ethyl-phenyl)-[2-(5-trifluoromethyl-pyridin-2-yl)-ethyl]-amine (MS m/e: 295.2 [M+H]+) was prepared from 1-bromo-4-ethyl-benzene instead of 6-bromo-2,3-dihydro-benzofuran and 2-(5-trifluoromethyl-pyridin-2-yl)-ethylamine instead of 2-(6-trifluoromethyl-pyridin-3-yl)-ethylamine.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08133909B2
Source datasetuspto-grants-2012_03
ORD IDord-6cf4e78b43c74dfeb805e948adc3b76c
Source noteuspto-grants-2012_03