1-Bromo-4-cyclopropylbenzene → HCID 58007557, compound

HRID 1094428Notes

Reaction equation

HRID 1094428 reaction equation
Br[C:2]1[CH:7]=[CH:6][C:5]([CH:8]2[CH2:10][CH2:9]2)=[CH:4][CH:3]=1.[F:11][C:12]([F:23])([F:22])[C:13]1[CH:14]=[CH:15][C:16]([CH2:19][CH2:20][NH2:21])=[N:17][CH:18]=1>>[CH:8]1([C:5]2[CH:6]=[CH:7][C:2]([NH:21][CH2:20][CH2:19][C:16]3[CH:15]=[CH:14][C:13]([C:12]([F:23])([F:11])[F:22])=[CH:18][N:17]=3)=[CH:3][CH:4]=2)[CH2:10][CH2:9]1

Participants

3

Reactant 2

HCID 122213551-Bromo-4-cyclopropylbenzeneHCID 180713442-(5-Trifluoromethyl-pyridin-2-YL)-ethylamine

Product 1

HCID 58007557HCID 58007557, compound

Procedure

In analogy to the procedure described for the synthesis example 71 (step 1), the title compound (4-cyclopropyl-phenyl)-[2-(5-trifluoromethyl-pyridin-2-yl)-ethyl]-amine (MS m/e: 307.2 [M+H]+) was prepared from 1-bromo-4-cyclopropyl-benzene instead of 6-bromo-2,3-dihydro-benzofuran and 2-(5-trifluoromethyl-pyridin-2-yl)-ethylamine instead of 2-(6-trifluoromethyl-pyridin-3-yl)-ethylamine.

Workup

  1. customIn analogy to the procedure described for the synthesis example 71 (step 1)

Sources & evidence

ORD record
ord-8de98918bfa34ceba303994f19e333a5
Source dataset
uspto-grants-2012_03
Patent number
US08133909B2

Reaction notes

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