2-(5-Trifluoromethyl-pyridin-2-YL)-ethylamine → (3,4-Bis-difluoromethoxy-phenyl)-[2-(5-trifluoromethyl-pyridin-2-yl)-ethyl]-amine

HRID 1094434Notes

Reaction equation

HRID 1094434 reaction equation
[F:1][CH:2]([F:15])[O:3][C:4]1[CH:9]=[CH:8][C:7](I)=[CH:6][C:5]=1[O:11][CH:12]([F:14])[F:13].[F:16][C:17]([F:28])([F:27])[C:18]1[CH:19]=[CH:20][C:21]([CH2:24][CH2:25][NH2:26])=[N:22][CH:23]=1>>[F:13][CH:12]([F:14])[O:11][C:5]1[CH:6]=[C:7]([NH:26][CH2:25][CH2:24][C:21]2[CH:20]=[CH:19][C:18]([C:17]([F:28])([F:16])[F:27])=[CH:23][N:22]=2)[CH:8]=[CH:9][C:4]=1[O:3][CH:2]([F:15])[F:1]

Participants

3

Reactant 2

HCID 180713442-(5-Trifluoromethyl-pyridin-2-YL)-ethylamineHCID 66637781HCID 66637781, compound

Product 1

HCID 58007488(3,4-Bis-difluoromethoxy-phenyl)-[2-(5-trifluoromethyl-pyridin-2-yl)-ethyl]-amine

Procedure

In analogy to the procedure described for the synthesis example 71 (step 1), the title compound (3,4-bis-difluoromethoxy-phenyl)-[2-(5-trifluoromethyl-pyridin-2-yl)-ethyl]-amine (MS m/e: 399.1 [M+H]+) was prepared from 1,2-bis-difluoromethoxy-4-iodo-benzene instead of 6-bromo-2,3-dihydro-benzofuran and 2-(5-trifluoromethyl-pyridin-2-yl)-ethylamine instead of 2-(6-trifluoromethyl-pyridin-3-yl)-ethylamine.

Workup

  1. customIn analogy to the procedure described for the synthesis example 71 (step 1)

Sources & evidence

ORD record
ord-3a6bf196eadf464c91ab6b9eabf2afc2
Source dataset
uspto-grants-2012_03
Patent number
US08133909B2

Reaction notes

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