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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1094434Generated: October 27, 2026

2-(5-Trifluoromethyl-pyridin-2-YL)-ethylamine → (3,4-Bis-difluoromethoxy-phenyl)-[2-(5-trifluoromethyl-pyridin-2-yl)-ethyl]-amine

https://huagongshe.com/reaction/1094434

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-(5-Trifluoromethyl-pyridin-2-YL)-ethylamineHCID 18071344—
ReactantHCID 66637781HCID 66637781—
Product(3,4-Bis-difluoromethoxy-phenyl)-[2-(5-trifluoromethyl-pyridin-2-yl)-ethyl]-amineHCID 58007488—

Reaction Steps

In analogy to the procedure described for the synthesis example 71 (step 1), the title compound (3,4-bis-difluoromethoxy-phenyl)-[2-(5-trifluoromethyl-pyridin-2-yl)-ethyl]-amine (MS m/e: 399.1 [M+H]+) was prepared from 1,2-bis-difluoromethoxy-4-iodo-benzene instead of 6-bromo-2,3-dihydro-benzofuran and 2-(5-trifluoromethyl-pyridin-2-yl)-ethylamine instead of 2-(6-trifluoromethyl-pyridin-3-yl)-ethylamine.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08133909B2
Source datasetuspto-grants-2012_03
ORD IDord-3a6bf196eadf464c91ab6b9eabf2afc2
Source noteuspto-grants-2012_03