2-(5-Trifluoromethyl-pyridin-2-YL)-ethylamine → HCID 58007559, compound

HRID 1094438Notes

Reaction equation

HRID 1094438 reaction equation
Br[C:2]1[CH:7]=[CH:6][C:5]([Cl:8])=[C:4]([O:9][CH:10]2[CH2:12][CH2:11]2)[CH:3]=1.[F:13][C:14]([F:25])([F:24])[C:15]1[CH:16]=[CH:17][C:18]([CH2:21][CH2:22][NH2:23])=[N:19][CH:20]=1>>[Cl:8][C:5]1[CH:6]=[CH:7][C:2]([NH:23][CH2:22][CH2:21][C:18]2[CH:17]=[CH:16][C:15]([C:14]([F:25])([F:13])[F:24])=[CH:20][N:19]=2)=[CH:3][C:4]=1[O:9][CH:10]1[CH2:12][CH2:11]1

Participants

3

Reactant 2

HCID 180713442-(5-Trifluoromethyl-pyridin-2-YL)-ethylamineHCID 580075714-bromo-1-chloro-2-cyclopropoxybenzene

Product 1

HCID 58007559HCID 58007559, compound

Procedure

In analogy to the procedure described for the synthesis example 71 (step 1), the title compound (4-chloro-3-cyclopropoxy-phenyl)-[2-(5-trifluoromethyl-pyridin-2-yl)-ethyl]-amine (MS m/e: 357.1 [M+H]+) was prepared from (4-bromo-1-chloro-2-cyclopropoxy-benzene instead of 6-bromo-2,3-dihydro-benzofuran and 2-(5-trifluoromethyl-pyridin-2-yl)-ethylamine instead of 2-(6-trifluoromethyl-pyridin-3-yl)-ethylamine.

Workup

  1. customIn analogy to the procedure described for the synthesis example 71 (step 1)

Sources & evidence

ORD record
ord-2e5160ff40b14206b0de85f1d0a9df00
Source dataset
uspto-grants-2012_03
Patent number
US08133909B2

Reaction notes

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