Hydrochloric Acid → HCID 66638974, compound

Participants

Reaction Steps

To a solution of 2-[(E)-(R)-3-dibenzylamino-4-(2-fluoro-phenyl)-but-1-enyl]-nicotinic acid methyl ester (0.7 g, 1.4 mmol) in 5 mL of a 1:1 dioxane:water solution is added lithium hydroxide (0.07 g, 2.8 mmol). After stirring for 24 hours, the reaction is diluted with water and is neutralized by addition of 1N HCl. Filtration gives the title compound.

Provenance & Evidence