Hydrochloric Acid → HCID 66638974, compound

HRID 1094463Notes

Reaction equation

HRID 1094463 reaction equation
C[O:2][C:3](=[O:36])[C:4]1[CH:9]=[CH:8][CH:7]=[N:6][C:5]=1/[CH:10]=[CH:11]/[C@H:12]([N:21]([CH2:29][C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=1)[CH2:22][C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1)[CH2:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=1[F:20].[OH-].[Li+].Cl>O1CCOCC1.O>[CH2:29]([N:21]([CH2:22][C:23]1[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=1)[C@H:12]([CH2:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=1[F:20])/[CH:11]=[CH:10]/[C:5]1[N:6]=[CH:7][CH:8]=[CH:9][C:4]=1[C:3]([OH:36])=[O:2])[C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=1

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 3939Lithium HydroxideHCID 66638929HCID 66638929, compound

Product 1

HCID 66638974HCID 66638974, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolvent2×HCID 312751,4-DioxaneSolvent

Procedure

To a solution of 2-[(E)-(R)-3-dibenzylamino-4-(2-fluoro-phenyl)-but-1-enyl]-nicotinic acid methyl ester (0.7 g, 1.4 mmol) in 5 mL of a 1:1 dioxane:water solution is added lithium hydroxide (0.07 g, 2.8 mmol). After stirring for 24 hours, the reaction is diluted with water and is neutralized by addition of 1N HCl. Filtration gives the title compound.

Workup

  1. filtrationFiltration

Sources & evidence

ORD record
ord-1f30967dd40741c0b93f8b7f2fe18d93
Source dataset
uspto-grants-2012_03
Patent number
US08133907B2

Reaction notes

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