Tert-Butylamine → HCID 66639627, compound

HRID 1094464Notes

Reaction equation

[CH2:1]([N:8]([CH2:29][C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=1)[C@H:9]([CH2:21][C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=1[F:28])/[CH:10]=[CH:11]/[C:12]1[N:20]=[CH:19][CH:18]=[CH:17][C:13]=1[C:14](O)=[O:15])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:36]([NH2:40])([CH3:39])([CH3:38])[CH3:37]>>[C:36]([NH:40][C:14](=[O:15])[C:13]1[CH:17]=[CH:18][CH:19]=[N:20][C:12]=1/[CH:11]=[CH:10]/[C@H:9]([N:8]([CH2:1][C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1)[CH2:29][C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=1)[CH2:21][C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=1[F:28])([CH3:39])([CH3:38])[CH3:37]

Participants

Reactant 2

HCID 6385Tert-Butylamine

HCID 66638974HCID 66638974, compound

Product 1

HCID 66639627HCID 66639627, compound

Procedure

Using general procedure 5 with 2-[(E)-(R)-3-dibenzylamino-4-(2-fluoro-phenyl)-but-1-enyl]-nicotinic acid (0.64 g, 1.4 mmol) and tert-butylamine (0.73 mL, 1.5 mmol) gives the title compound.

Sources & evidence

ORD record: ord-185e95b7113a4c31b21a37083b8b16eb
Source dataset: uspto-grants-2012_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08133907B2

Reaction notes

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