HCID 66639636, compound → HCID 59799809, compound

HRID 1094468Notes

Reaction equation

HRID 1094468 reaction equation
C(OC(=O)[NH:7][C@H:8]([CH2:24][C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=1[F:31])[C@@H:9]([OH:23])[CH2:10][C:11]1[C:16]([C:17](=[O:22])[NH:18][CH:19]([CH3:21])[CH3:20])=[CH:15][CH:14]=[CH:13][N:12]=1)(C)(C)C>CCCCC>[NH2:7][C@H:8]([CH2:24][C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=1[F:31])[C@@H:9]([OH:23])[CH2:10][C:11]1[N:12]=[CH:13][CH:14]=[CH:15][C:16]=1[C:17]([NH:18][CH:19]([CH3:20])[CH3:21])=[O:22]

Participants

3

Reactant 1

HCID 66639636HCID 66639636, compound

Product 1

HCID 59799809HCID 59799809, compound

Reagents, catalysts & solvents 1

HCID 8003PentaneSolvent

Procedure

Using general deprotection procedure 5 with [(1R,2S)-1-(2-Fluoro-benzyl)-2-hydroxy-3-(3-isopropylcarbamoyl-pyridin-2-yl)-propyl]-carbamic acid tert-butyl ester (0.16 g, 0.34 mmol) followed by trituration with pentane gives the title compound.

Sources & evidence

ORD record
ord-dabc4a213cc34ef58246f9e482425f9c
Source dataset
uspto-grants-2012_03
Patent number
US08133907B2

Reaction notes

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