HCID 66640700, compound → HCID 57556440, compound

HRID 1094530Notes

Reaction equation

HRID 1094530 reaction equation
[CH3:1][N:2]1[CH2:7][CH2:6][C:5](=[CH:8][C:9]2[CH:14]=[CH:13][C:12]([NH2:15])=[CH:11][C:10]=2[C:16]([F:19])([F:18])[F:17])[CH2:4][CH2:3]1>CCO>[CH3:1][N:2]1[CH2:3][CH2:4][CH:5]([CH2:8][C:9]2[CH:14]=[CH:13][C:12]([NH2:15])=[CH:11][C:10]=2[C:16]([F:17])([F:19])[F:18])[CH2:6][CH2:7]1

Participants

3

Reactant 1

HCID 66640700HCID 66640700, compound

Product 1

HCID 57556440HCID 57556440, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 2.2 g (8.15 mMol) 4-(1-methyl-piperidin-4-ylidenemethyl)-3-trifluoromethyl-phenylamine in 50 ml EtOH is hydrogenated in the presence of PVC for 32 h at ambient temperature. The catalyst is then removed by filtration over hyflo and the solvent is evaporated off under reduced pressure to give the crude product which is purified by column chromatography (SiO2; CH2Cl2/EtOH/NH3 95:4.5:0.5) to afford the title compound as a beige solid.

Workup

  1. customThe catalyst is then removed by filtration over hyflo
  2. customthe solvent is evaporated off under reduced pressure
  3. customto give the crude product which
  4. customis purified by column chromatography (SiO2; CH2Cl2/EtOH/NH3 95:4.5:0.5)

Sources & evidence

ORD record
ord-fd182e58edab4eb49caeaca0153017f0
Source dataset
uspto-grants-2012_03
Patent number
US08133886B2

Reaction notes

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