HCID 66640700, compound → HCID 57556440, compound

Participants

Reaction Steps

A solution of 2.2 g (8.15 mMol) 4-(1-methyl-piperidin-4-ylidenemethyl)-3-trifluoromethyl-phenylamine in 50 ml EtOH is hydrogenated in the presence of PVC for 32 h at ambient temperature. The catalyst is then removed by filtration over hyflo and the solvent is evaporated off under reduced pressure to give the crude product which is purified by column chromatography (SiO2; CH2Cl2/EtOH/NH3 95:4.5:0.5) to afford the title compound as a beige solid.

Provenance & Evidence