HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1094616Generated: October 26, 2026
Water → 1-(1-benzyl-1H-indol-3-yl)cyclopentanecarbonitrile
https://huagongshe.com/reaction/1094616
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 1-benzyl-1H-indol-3-ylacetonitrile | HCID 11032169 | — |
| Solvent | Hexane | HCID 8058 | — |
| Product | 1-(1-benzyl-1H-indol-3-yl)cyclopentanecarbonitrile | HCID 10709379 | — |
Reaction Steps
To a suspension of sodium hydride (60%, 2.26 g, 56 mmol) was added a solution of 1-benzyl-1H-indol-3-ylacetonitrile in DMSO-ether (10 MI: 80 mL) dropwise and the mixture was stirred for 5 hours at 20° C. Water and hexane were added. Solid was collected by filtration and washed with water and hexane to give 1-(1-benzyl-1H-indol-3-yl)cyclopentanecarbonitrile (5.3 g). MS (ES): 301 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08133992B2 |
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| Source dataset | uspto-grants-2012_03 |
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| ORD ID | ord-56d412bcc2154847b984054e39aba7b7 |
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| Source note | uspto-grants-2012_03 |
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