反应详情

To a suspension of methyl 5-methyl-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-6-carboxylate (2.69 g, 12 mmol) in CH3CN (30 mL) was added K2CO3 (2.01 g, 14.5 mmol), KI (2.0 g, 12 mmol), and N-tert-butyl-2-chloroacetamide (1.8 g, 12 mmol). The reaction mixture was refluxed overnight and quenched with H2O (150 mL). The resulting precipitate was filtered and dried to afford methyl 3-(2-(tert-butylamino)-2-oxoethyl)-5-methyl-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-6-carboxylate, as a solid (yield: quantitative).

1. temperatureThe reaction mixture was refluxed overnight
2. customquenched with H2O (150 mL)
3. filtrationThe resulting precipitate was filtered
4. customdried