Chloroacetyl chloride → 2-Chloro-N-cyclohexylacetamide

To a cooled (0° C.) solution of cyclohexylamine (2.31 mL, 20 mmol) in DCM (20 mL) was added triethylamine (5.7 mL, 40 mmol) followed by chloro acetylchloride (1.61 mL, 20 mmol). The reaction was warmed to RT and stirred for 3 h. The reaction mixture was concentrated, redissolved in EtOAc (20 mL) and washed with brine. The organic layer was dried over anhydrous Na2SO4 and concentrated to yield crude product which was further purified by flash column chromatography using 7:3 Pet. Ether:EtOAc as the eluant. 1.8 g of pure 2-chloro-N-cyclohexylacetamide was isolated.

1. concentrationThe reaction mixture was concentrated
2. dissolutionredissolved in EtOAc (20 mL)
3. washwashed with brine
4. dry with materialThe organic layer was dried over anhydrous Na2SO4
5. concentrationconcentrated
6. customto yield crude product which
7. customwas further purified by flash column chromatography

ORD record

ord-3a930a634e7543ed979a0a2e51f60c3e

Source dataset

uspto-grants-2012_03

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08133998B2