反应详情

温度

180 °C

A mixture of 2-amino terephthalic acid (2 g, 11 mmol) and formamide (10 mL) was heated at 180° C. for 5 h. The reaction mixture was cooled to RT and acetone was added. The solid precipitated thus obtained was stirred for 2 h, filtered and dried to give 4-oxo-3,4-dihydroquinazoline-7-carboxylic acid in 80% yield.

1. temperatureThe reaction mixture was cooled to RT
2. customThe solid precipitated thus
3. customobtained
4. filtrationfiltered
5. customdried