HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1094728Generated: October 26, 2026
Formamide → 4-Oxo-3,4-dihydroquinazoline-7-carboxylic acid
https://huagongshe.com/reaction/1094728
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Formamide | HCID 713 | — |
| Reactant | 2-Aminoterephthalic acid | HCID 2724822 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | 4-Oxo-3,4-dihydroquinazoline-7-carboxylic acid | HCID 135483588 | 80% |
Reaction Steps
A mixture of 2-amino terephthalic acid (2 g, 11 mmol) and formamide (10 mL) was heated at 180° C. for 5 h. The reaction mixture was cooled to RT and acetone was added. The solid precipitated thus obtained was stirred for 2 h, filtered and dried to give 4-oxo-3,4-dihydroquinazoline-7-carboxylic acid in 80% yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08133998B2 |
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| Source dataset | uspto-grants-2012_03 |
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| ORD ID | ord-5c776617c0e549368e39fa55bb317b23 |
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| Source note | uspto-grants-2012_03 |
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