反应详情

温度

100 °C

An alternative method to make D19 is as follows: 6-methyl-3-(2-pyrimidinyl)-2-pyridinecarbonitrile D18 (0.481 g) was suspended in EtOH (5 ml) and a solution of NaOH (0.490 g, 12.26 mmol) in water (5 ml) was added. The yellow mixture was stirred at 100° C. overnight. The yellow solution was cooled to 25° C. and HCl 6 M (1.0 ml) was added dropwise till pH=4.5. The solvent was removed to give a yellow powder that was dried at 50° C./vacuum for 1.5 hours to give the title compound D19 (1.242 g).

1. temperatureThe yellow solution was cooled to 25° C.
2. customThe solvent was removed
3. customto give a yellow powder that
4. customwas dried at 50° C./vacuum for 1.5 hours