Isopropyl Acetate → 3-(2-(Trifluoromethoxy)phenyl)pyridine-2,6-diamine

Temperature

78 °C

To a suspension of 3-iodopyridine-2,6-diamine (5 g, 21 mmol), 2-(trifluoromethoxy)phenyl boronic acid (4.82 g, 23 mmol) and sodium carbonate (2.48 g, 23 mmol) in ethanol (25 ml) and water (25 ml) was added tris(dibenzylideneacetone)dipalladium (0.292 g, 0.319 mmol) followed by tri-tert-butylphosphine (1M solution in toluene, 0.957 ml, 0.957 mmol). The reaction was heated to 78° C. for 16 hours before cooling to room temperature and addition of isopropylacetate (50 ml). The bi-phasic mixture was filtered through Arbocel™ and the filter cake washed with isopropylacetate (2×25 ml). The layers were separated and the organic phase washed with half saturated aqueous sodium hydrogen carbonate solution (50 ml) and water (2×25 ml) before concentration in vacuo. Toluene (2×25 ml) was added during the concentration process and evaporation continued to dryness. The crude residue was purified using silica gel column chromatography (Biotage™) eluting with isopropanol:toluene 5:95 to furnish the title compound as a solid, 90%.

1. temperaturebefore cooling to room temperature
2. filtrationThe bi-phasic mixture was filtered through Arbocel™
3. washthe filter cake washed with isopropylacetate (2×25 ml)
4. customThe layers were separated
5. washthe organic phase washed with half saturated aqueous sodium hydrogen carbonate solution (50 ml) and water (2×25 ml) before concentration in vacuo
6. additionToluene (2×25 ml) was added during the concentration process and evaporation
7. customThe crude residue was purified
8. washeluting with isopropanol:toluene 5:95

ORD record

ord-475bd5dc23bf4306b035aaf825767aed

Source dataset

uspto-grants-2012_03

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08134007B2