反应详情

1-Bromo-3-chloro-5-methoxybenzene (Preparation 22, 6.0 g, 27 mmol) and trichloroisocyanuric acid (2.3 g, 9.9 mmol) were stirred in dimethylformamide (100 ml) at 50° C. for 3 hours. N-Heptane was added and the mixture filtered to remove insoluble impurities. The mixture was then concentrated in vacuo and the residue purified by silica gel column chromatography, eluting with 90:10 heptane:ethyl acetate to afford the title compound as a white solid (5.0 g).

1. filtrationthe mixture filtered
2. customto remove insoluble impurities
3. concentrationThe mixture was then concentrated in vacuo
4. customthe residue purified by silica gel column chromatography
5. washeluting with 90:10 heptane