1-Bromo-2,5-dichloro-3-fluorobenzene → 1-Bromo-2,5-dichloro-3-methoxybenzene

HRID 1094795Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1094795
[Br:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[C:4](F)[C:3]=1[Cl:10].[CH3:11][O-:12].[Na+]>CO>[Br:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[C:4]([O:12][CH3:11])[C:3]=1[Cl:10]

Komponenten

4

Edukt 2

HCID 6185131-Bromo-2,5-dichloro-3-fluorobenzeneHCID 10942334Sodium Methoxide

Produkt 1

HCID 577991361-Bromo-2,5-dichloro-3-methoxybenzeneAusbeute 97,7 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

1-Bromo-2,5-dichloro-3-fluorobenzene (40 g, 160 mmol) and sodium methoxide (44.3 g, 820 mmol) were stirred in methanol (500 ml) at reflux for 16 hours. The reaction was cooled to ambient temperature then quenched with water (500 ml). The mixture was extracted with diethyl ether (3×300 ml), dried over Na2SO4 and evaporated to afford the title compound as a white solid (40 g).

Aufarbeitung

  1. temperatureat reflux for 16 hours
  2. customthen quenched with water (500 ml)
  3. extractionThe mixture was extracted with diethyl ether (3×300 ml)
  4. dry with materialdried over Na2SO4
  5. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-d9d05e45b9fb42679eaa38269b745f41
Quelldatensatz
uspto-grants-2012_03
Patentnummer
US08134007B2

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