反应详情

1-Bromo-2,5-dichloro-3-fluorobenzene (40 g, 160 mmol) and sodium methoxide (44.3 g, 820 mmol) were stirred in methanol (500 ml) at reflux for 16 hours. The reaction was cooled to ambient temperature then quenched with water (500 ml). The mixture was extracted with diethyl ether (3×300 ml), dried over Na2SO4 and evaporated to afford the title compound as a white solid (40 g).

1. temperatureat reflux for 16 hours
2. customthen quenched with water (500 ml)
3. extractionThe mixture was extracted with diethyl ether (3×300 ml)
4. dry with materialdried over Na2SO4
5. customevaporated