HCID 57758195, compound → HCID 66641291, compound

HRID 1094914Notes

Reaction equation

HRID 1094914 reaction equation
[NH2:1][C:2]1[C:7]2=[C:8]([C:14]3[CH:19]=[CH:18][C:17]([NH:20][C:21]([NH:23][C:24]4[CH:29]=[C:28]([C:30]([F:33])([F:32])[F:31])[CH:27]=[CH:26][C:25]=4[F:34])=[O:22])=[C:16](F)[CH:15]=3)[C:9]([CH2:11][O:12][CH3:13])=[CH:10][N:6]2[N:5]=[CH:4][N:3]=1.[Cl-:36].[CH3:37][N+:38]1[CH2:39][CH2:40][O:41][CH2:42][CH:43]=1>CN(C=O)C>[ClH:36].[NH2:1][C:2]1[C:7]2=[C:8]([C:14]3[CH:19]=[CH:18][C:17]([NH:20][C:21]([NH:23][C:24]4[CH:29]=[C:28]([C:30]([F:33])([F:31])[F:32])[CH:27]=[CH:26][C:25]=4[F:34])=[O:22])=[CH:16][CH:15]=3)[C:9]([CH2:11][O:12][CH3:13])=[C:10]([CH:43]3[CH2:42][O:41][CH2:40][CH2:39][N:38]3[CH3:37])[N:6]2[N:5]=[CH:4][N:3]=1

Participants

4

Reactant 2

HCID 57758195HCID 57758195, compoundHCID 666412974-methyl-3,6-dihydro-2H-1,4-oxazin-4-ium chloride

Product 1

HCID 66641291HCID 66641291, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

A solution of Intermediate AB (N-{4-[4-amino-6-(methoxymethyl)pyrrolo[2,1-f][1,2,4]triazin-5-yl]-2-fluorophenyl}-N′-[2-fluoro-5-(trifluoromethyl)-phenyl]urea (200 mg, 0.42 mmol) and 4-methyl-3,6-dihydro-2H-1,4-oxazin-4-ium chloride (69 mg, 0.51 mmol) in DMF (5 mL) is allowed to stir for 1 h at rt. Volatiles are removed in vacuo, and the residue triturated with CH2Cl2, providing the desired compound.

Workup

  1. customVolatiles are removed in vacuo
  2. customthe residue triturated with CH2Cl2

Sources & evidence

ORD record
ord-0661eb6fab8247bba7d598290cbd6a3d
Source dataset
uspto-grants-2012_03
Patent number
US08133995B2

Reaction notes

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