Hydrazine hydrate (1:1) → HCID 60206781, compound

HRID 1094922Notes

Reaction equation

HRID 1094922 reaction equation
[N:1]1([CH2:6][CH2:7][NH:8][C:9]([C:11]2[S:15][C:14]([C:16]([O:18]C)=O)=[CH:13][CH:12]=2)=[O:10])[CH2:5][CH2:4][CH2:3][CH2:2]1.O.[NH2:21][NH2:22]>C(O)C>[N:1]1([CH2:6][CH2:7][NH:8][C:9]([C:11]2[S:15][C:14]([C:16]([NH:21][NH2:22])=[O:18])=[CH:13][CH:12]=2)=[O:10])[CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 60206770HCID 60206770, compound

Product 1

HCID 60206781HCID 60206781, compoundYield 38%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Methyl 5-[2-(pyrrolidin-1-yl)ethylcarbamoyl]-thiophene-2-carboxylate (56 mg, 0.2 mmol) in ethanol (2.0 mL) was refluxed with heating with hydrazine monohydrate (0.10 mL) for 10 hours and allowed to cool to room temperature, and the precipitated solid was collected by filtration, washed with water and dried to give 21 mg of the desired product (yield 38%).

Workup

  1. filtrationthe precipitated solid was collected by filtration
  2. washwashed with water
  3. customdried

Sources & evidence

ORD record
ord-3ced9a2c2f9c4adfacdc7cca263d2135
Source dataset
uspto-grants-2012_03
Patent number
US08134013B2

Reaction notes

Loading…