Hydrazine hydrate (1:1) → HCID 91507662, compound

HRID 1094923Notes

Reaction equation

HRID 1094923 reaction equation
[C:1]([O:5][C:6]([CH2:8][NH:9][C:10]([C:12]1[S:16][C:15]([C:17]([O:19]C)=O)=[CH:14][CH:13]=1)=[O:11])=[O:7])([CH3:4])([CH3:3])[CH3:2].O.[NH2:22][NH2:23]>C(O)C>[C:1]([O:5][C:6](=[O:7])[CH2:8][NH:9][C:10]([C:12]1[S:16][C:15]([C:17]([NH:22][NH2:23])=[O:19])=[CH:14][CH:13]=1)=[O:11])([CH3:4])([CH3:3])[CH3:2]

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 60206776HCID 60206776, compound

Product 1

HCID 91507662HCID 91507662, compoundYield 71%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Methyl 5-(tert-butoxycarbonylmethylcarbamoyl)thiophene-2-carboxylate (63 mg, 0.21 mmol) in ethanol (3.0 mL) was refluexed with heating with hydrazine monohydrate (0.13 mL) for 8 hours and allowed to cool to room temperature. The reaction mixture was concentrated under reduced pressure, and water was added. The precipitated solid was collected by filtration, washed with water and dried to give 44 mg of the desired product (yield 71%).

Workup

  1. concentrationThe reaction mixture was concentrated under reduced pressure, and water
  2. additionwas added
  3. filtrationThe precipitated solid was collected by filtration
  4. washwashed with water
  5. customdried

Sources & evidence

ORD record
ord-3f137ccf60d14426a4681cc343779be6
Source dataset
uspto-grants-2012_03
Patent number
US08134013B2

Reaction notes

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