Hydrazine hydrate (1:1) → HCID 60206778, compound

HRID 1094924Notes

Reaction equation

HRID 1094924 reaction equation
[CH3:1][N:2]1[CH2:7][CH2:6][N:5]([NH:8][C:9]([C:11]2[S:15][C:14]([C:16]([O:18]C)=O)=[CH:13][CH:12]=2)=[O:10])[CH2:4][CH2:3]1.O.[NH2:21][NH2:22]>C(O)C>[CH3:1][N:2]1[CH2:7][CH2:6][N:5]([NH:8][C:9]([C:11]2[S:15][C:14]([C:16]([NH:21][NH2:22])=[O:18])=[CH:13][CH:12]=2)=[O:10])[CH2:4][CH2:3]1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 57421773HCID 57421773, compound

Product 1

HCID 60206778HCID 60206778, compoundYield 65%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Methyl 5-(4-methylpiperazin-1-ylcarbamoyl)thiophene-2-carboxylate (218 mg, 0.77 mmol) in ethanol (60 mL) was refluexed with heating with hydrazine monohydrate (0.40 mL) for 6 hours and allowed to cool to room temperature, and the solvent was evaporated at 40° C. mL of diethyl ether was added to the resulting oil, and the precipitated solid was collected by filtration, washed with water and dried to give 142 mg of the desired product (yield 65%).

Workup

  1. customthe solvent was evaporated at 40° C.
  2. additionof diethyl ether was added to the resulting oil
  3. filtrationthe precipitated solid was collected by filtration
  4. washwashed with water
  5. customdried

Sources & evidence

ORD record
ord-41257d7b05d64363afff2b1a194b01d5
Source dataset
uspto-grants-2012_03
Patent number
US08134013B2

Reaction notes

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