Hydrazine hydrate (1:1) → HCID 57908423, compound

HRID 1094925Notes

Reaction equation

HRID 1094925 reaction equation
[N:1]1([NH:7][C:8]([C:10]2[S:14][C:13]([C:15]([O:17]C)=O)=[CH:12][CH:11]=2)=[O:9])[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.O.[NH2:20][NH2:21]>C(O)C>[N:1]1([NH:7][C:8]([C:10]2[S:14][C:13]([C:15]([NH:20][NH2:21])=[O:17])=[CH:12][CH:11]=2)=[O:9])[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 57421774HCID 57421774, compound

Product 1

HCID 57908423HCID 57908423, compoundYield 68%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Methyl 5-(morpholin-4-ylcarbamoyl)thiophene-2-carboxylate (237 mg, 0.87 mmol) in ethanol (6.0 mL) was refluexed with heating with hydrazine monohydrate (0.40 mL) for 6 hours and allowed to cool to room temperature and the solvent was evaporated at 40° C. 5 mL of diethyl ether was added to the resulting oil, and the precipitated solid was collected by filtration, washed with water and dried to give 160 mg of the desired product (yield 68%).

Workup

  1. customthe solvent was evaporated at 40° C
  2. addition5 mL of diethyl ether was added to the resulting oil
  3. filtrationthe precipitated solid was collected by filtration
  4. washwashed with water
  5. customdried

Sources & evidence

ORD record
ord-59c79585317c4773ba9f8da880c09dea
Source dataset
uspto-grants-2012_03
Patent number
US08134013B2

Reaction notes

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