HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → 4-(4-Chloro-3-fluoro-2-formyl-phenoxy)-piperidine-1-carboxylic acid tert-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 1-(tert-Butoxycarbonyl)-4-(p-toluenesulfonyloxy)piperidine | HCID 15734713 | — |
| Reactant | 3-Chloro-2-fluoro-6-hydroxybenzaldehyde | HCID 58934790 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 4-(4-Chloro-3-fluoro-2-formyl-phenoxy)-piperidine-1-carboxylic acid tert-butyl ester | HCID 57743245 | 106.1% |
Reaction Steps
In a manner similar to the method described in example 4a, 3-chloro-2-fluoro-6-hydroxy-benzaldehyde (2.07 g, 11.8 mmol) reacted with 4-(toluene-4-sulfonyloxy)-piperidine-1-carboxylic acid tert-butyl ester (3.51 g, 9.88 mmol, ASTATECH) and K2CO3 in N,N-dimethylformamide to give 4-(4-chloro-3-fluoro-2-formyl-phenoxy)-piperidine-1-carboxylic acid tert-butyl ester as a brown oil (Yield 3.75 g, 84%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08134001B2 |
| Source dataset | uspto-grants-2012_03 |
| ORD ID | ord-6b0bd87dbdf14a48b24e2ba56729b749 |
| Source note | uspto-grants-2012_03 |